5 Key Takeaways

• 1

  Intravenous tenecteplase prior to endovascular treatment did not improve functional independence at 90 days in acute ischemic stroke patients.

• 2

  The TNK-PLUS trial enrolled 391 adults with proximal middle cerebral artery occlusion, comparing tenecteplase plus EVT to EVT alone.

• 3

  Functional independence was achieved in 44% of the tenecteplase group and 43% of the EVT-only group, with no significant difference.

• 4

  Reperfusion rates were slightly higher in the tenecteplase group, but this did not translate to better functional outcomes.

• 5

  The trial's findings may not apply to patients without immediate access to endovascular treatment due to different thrombolytic dwell times.