Germline mutations in POLE and POLD1 are linked to variable cancer risks, with findings highlighting mutation-specific differences that refine tumor predisposition assessment.
"These data highlight the role of subjective patient-related parameters in the response to cytokine inhibition and suggest that a high-volume representation of the disease in the CNS—involving more frontal-associative brain circuits—increases the likelihood to respond to TNF inhibitor.
Cognitive functional therapy demonstrates durable effects on disability and pain intensity at 3 years, with outcomes remaining stable beyond the 12-month mark in patients with chronic low back pain