Objective:

To evaluate the effects of high-dose intravenous vitamin C on mortality and persistent organ dysfunction in patients with severe burn injuries.

Approach:

Key Findings:

• 41% of patients receiving high-dose vitamin C experienced the primary outcome compared to 30% in the placebo group.
• Adjusted risk ratio crossed the futility/harm threshold, leading to trial termination.
• 28-day mortality was 15% in the vitamin C group versus 8% in the placebo group.
• No improvement in time to discharge alive from the hospital or persistent organ dysfunction-free days with vitamin C treatment.
• No evidence of benefit in any prespecified subgroup analysis.

Interpretation:

High-dose intravenous vitamin C did not reduce organ dysfunction or mortality in patients with severe burns.

Limitations:

• The study was terminated early due to futility.
• Findings may not be generalizable beyond the studied population.

Conclusion:

High-dose intravenous vitamin C should not be considered a treatment for severe burns.

Sources:

• JAMA Editorial
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