- Amputation rates among opioid-related hospitalizations increased from 56 to 92 per 10,000 hospitalizations between 2016 and 2022.
- The adjusted increase in amputation rates was greater among opioid-related than nonopioid-related hospitalizations by 13 additional amputations per 10,000 hospitalizations.
- The steepest regional increases were observed in the Northeast and West census regions.
- Opioid-related hospitalizations involved a higher proportion of upper-extremity and above-knee amputations than nonopioid-related hospitalizations.
- Researchers suggested xylazine contamination and injection-related infections as possible contributors, although these factors were not directly measured.
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