In a UK cohort, patients with osteoarthritis who initiated centrally acting analgesics had a higher hazard of knee or hip replacement than those who initiated SSRIs, though residual confounding by pain severity remains a key limitation.
Swedish registry analysis linked surgical treatment with better patient-reported function in comminuted intra-articular distal radius fractures, while other fracture patterns showed limited benefit.
Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.
Older patients with documented cognitive impairment also experienced greater postoperative functional decline following elective total knee arthroplasty