In a UK cohort, patients with osteoarthritis who initiated centrally acting analgesics had a higher hazard of knee or hip replacement than those who initiated SSRIs, though residual confounding by pain severity remains a key limitation.
A smartphone image–centered deep learning model showed promise for intraoperative diagnosis and grading of clinical stage IA lung adenocarcinoma, but grade-specific limitations and lack of outcomes data mean the tool remains investigational.
Swedish registry analysis linked surgical treatment with better patient-reported function in comminuted intra-articular distal radius fractures, while other fracture patterns showed limited benefit.
Older age, male sex, underweight status, reduced activities of daily living, and mild consciousness disturbance were associated with postextubation pneumonia in elective surgical patients.
FOXC1 duplications were the second most common monogenic finding among genetically solved juvenile open-angle glaucoma cases in one registry, supporting the use of copy-number variant analysis in early-onset glaucoma testing.
Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.