A case study chronicles an 85-year-old woman who developed systemic lupus erythematosus following her Shingrix vaccination, marking a unique association with the zoster vaccine. The patient, with hypertension and hypothyroidism, presented symptoms including pleuritic chest pain and weight loss within a week post-vaccination, exacerbating after the second dose. Confirmatory tests identified increased inflammatory markers and positive ANA, leading to a diagnosis of vaccine-induced lupus. Treatment with prednisone resulted in symptom resolution, highlighting the importance of monitoring post-vaccination autoimmune responses, especially among elderly patients.

Source: Clinical Rheumatology