5 Key Takeaways

• 1

  Dual-site accelerated intermittent theta burst stimulation may reduce suicidal ideation in adolescents with major depressive disorder compared to single-site stimulation.

• 2

  The randomized clinical trial involved 59 patients aged 12 to 18 years, diagnosed with major depressive disorder and exhibiting significant suicidal ideation.

• 3

  Mean Beck Scale for Suicide Ideation scores decreased more in the dual-site group, from 22.6 to 8.2, compared to the single-site group's decrease from 23.3 to 13.9.

• 4

  Response rates for suicidal ideation were 59% in the dual-site group and 37% in the single-site group, with remission rates of 48% and 30%, respectively.

• 5

  Common adverse events included pain at stimulation sites and dizziness, which resolved within approximately 30 minutes after treatment.