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Over 177,000 drug–drug interaction (DDI) reports were identified, with nearly half resulting in hospitalization and more than 8% in death.
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Frequently implicated drugs included warfarin, aspirin, sertraline, tacrolimus, and simvastatin—agents widely used across primary and specialty care.
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Omeprazole and metoclopramide contributed notably to disability-related DDIs, emphasizing risks associated with gastrointestinal agents that alter drug metabolism.
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Adults aged 65–85 and patients with multiple comorbidities faced the highest incidence of severe outcomes.
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Routine medication reconciliation and interspecialty communication remain critical to prevent avoidable adverse events from pharmacologic interactions.
Source: Medicine
