1. Severe caffeine intoxication can lead to life-threatening complications. 2. 40% of cases had suicidal intent. 3. Median caffeine ingestion was 12 g, with a serum concentration of 160 mg/L. 4. Extracorporeal blood purification improved survival rates (95%). 5. Tachycardia was observed in 87% of patients. 6. Treatment variability affected outcomes. 7. Higher doses (5–10 g) are potentially lethal. 8. Limitations in the data include retrospective design and potential publication bias.