- Study analyzed blood genomes from 23 chemotherapy-treated patients.
- Elevated somatic mutations noted in 17 patients.
- Mutation signatures linked to specific chemotherapy agents.
- 5-fluorouracil mutations occurred only in lymphoid cells.
- Study highlights long-term genomic impact of chemotherapy.
- Oxaliplatin caused fewer mutations compared to other agents.
- Some drugs affect specific blood cell types differently.
- Research suggests chemotherapy may accelerate hematopoietic aging.
Source: Nature Genetics