- T cell spatial organization is a critical prognostic marker for stage III colorectal cancer patients.
- The spatial arrangement of T cells, rather than their mere presence, can predict patient outcomes.
- CD8+ T cell density did not predict recurrence risk in stage III colorectal cancer.
- Tumor samples were analyzed using Cell DIVE, a multiplexed immunofluorescence imaging technique.
- Shorter distances between T cells and cancer cells were linked to better disease-free survival.
- Memorial Sloan Kettering Cancer Center conducted the study on 221 stage III CRC patients.
- Larger cohort studies are recommended to validate these findings.
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