Circulating Insulin-like peptide 5 concentrations may reflect colonic exposure to bile acids and help stratify treatment response in patients with chronic diarrhoea, including those with irritable bowel syndrome with diarrhoea and bile acid diarrhoea.
A 3-year analysis of a phase IIIb trial found that bimekizumab, a dual interleukin-17A and interleukin-17F inhibitor, maintained high rates of skin clearance and demonstrated a consistent safety profile in patients with moderate-to-severe plaque psoriasis, including those who switched from secukinumab, an interleukin-17A inhibitor.
A new meta-analysis of 11 randomized controlled trials found that patients began regaining weight as early as 8 weeks after discontinuing anti-obesity medications, with weight gain continuing through 52 weeks.