Persistent symptoms may be prevalent among patients with microscopic colitis, according to a recent study published by Redd et al in Gastro Hep Advances. Although microscopic colitis has been identified as a common cause of chronic diarrhea, its clinical course is not well understood. In a case-control study, researchers examined the outcomes of 74 patients with microscopic colitis and 162 controls with other causes of chronic diarrhea who were undergoing outpatient colonoscopy—with the goal of uncovering the symptom burden and routine clinical treatment of microscopic colitis. After a 1-year follow-up, the investigators found that 60% of the patients with microscopic colitis had been treated with antidiarrheal drugs and 46% of them had been treated with budesonide. Further, 40%, 32%, and 21% of patients with microscopic colitis had fecal urgency, weight loss, and fecal incontinence, respectively. However, compared with the patients with microscopic colitis, the controls had worse Microscopic Colitis Disease Activity Index scores and more frequent stools, fecal urgency, fecal incontinence, and abdominal pain. The investigators underscored that many of the patients with microscopic colitis had persistent symptoms and emphasized the need to communicate diagnostic colonoscopy findings with patients in order to ensure that they receive proper treatment. In a companion press release on the findings from the University of North Carolina at Chapel Hill, the study authors concluded: “Identifying and addressing gaps in the communication of diagnostic results … as well as [the assessment and treatment of] persistent symptoms following an initial diagnostic evaluation … is an important area for future research.”