1. Peyer’s patch B cells can directly capture transglutaminase 2 (TG2) from the gut lumen.
2. This process may initiate the hallmark TG2 autoantibody response in celiac disease.
3. HLA-DQ2.5 transgenic mice with TG2-specific B cells and gluten-specific T cells reproduced key immune features seen in patients.
4. Findings support a model where TG2–gluten complexes are taken up by B cells in gut-associated lymphoid tissue (GALT).
5. Results point to B-cell–directed therapies or TG2 enzyme inhibition as potential treatment strategies for celiac disease.
6. Naturally occurring TG2–gluten complex uptake was not directly shown, and roles of other antigen-presenting cells remain uncertain.

Source: Gastroenterology