A 72-week clinical study revealed that in patients with chronic hepatitis B and liver fibrosis, early decreases in liver stiffness measurements were predominantly due to reduced inflammation rather than fibrosis regression. Liver enzymes significantly decreased, and most patients experienced reductions in liver stiffness measurements, with improved liver inflammation scores but less improvement in fibrosis. The study highlighted the impact of inflammation on stiffness measurements and the need for long-term studies to refine fibrosis monitoring and treatment response strategies.

Source: Journal of Clinical Gastroenterology