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Conexiant chevron_right Gastroenterology chevron_right INSL5 Rise Tied to Diarrhoea Severity Treatment
From the Journals

INSL5 Rise Tied to Diarrhoea Severity, Treatment

Circulating Insulin-like peptide 5 concentrations may reflect colonic exposure to bile acids and help stratify treatment response in patients with chronic diarrhoea, including those with irritable bowel syndrome with diarrhoea and bile acid diarrhoea.

Conexiant
Full Article Summary Notecard
  1. Insulin-like peptide 5 (INSL5) levels are elevated in bile acid diarrhea and IBS.
  2. INSL5 correlates with stool consistency and urgency.
  3. Rectal taurocholic acid boosts INSL5 levels rapidly.
  4. INSL5 may predict response to ondansetron.
  5. First study to investigate INSL5 in chronic diarrhea.
  6. Future studies needed to assess INSL5's role in diarrhea severity.
  7. INSL5 does not rise postprandially, suggesting bile stimuli trigger its release.

Source: Gut

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