- LINE-1 hypomethylation is a key epigenetic marker related to the inflammatory response in coeliac disease and small bowel adenocarcinoma.
- Potential reversibility of epigenetic changes was noted through dietary intervention.
- The study highlights the interplay of epigenetic factors in chronic inflammatory conditions and their contribution to cancer risk.
- LINE-1 retrotransposons make up nearly 17% of the human genome and are tightly regulated by DNA methylation.
- Inflammatory gene expression in CeD-SBAs is akin to untreated CeD mucosae, indicating marked upregulation of genes involved in inflammation and T-cell activity.
Gluten-Free Diet Restores Key Epigenetic Marker in Coeliac Disease
Conexiant
December 3, 2024
