5 Key Takeaways

• 1

  Virulent Helicobacter pylori genotypes are linked to greater gastric microbial diversity and distinct bacterial communities.

• 2

  The study analyzed 66 H. pylori–positive gastric biopsies from Indonesia, a region with high gastritis but low gastric cancer rates.

• 3

  Virulent H. pylori genotypes showed greater microbial diversity compared to less virulent counterparts, despite non-significant overall α-diversity.

• 4

  Community composition varied by H. pylori pathogenic factors, with notable differences in genera like Veillonella and Klebsiella.

• 5

  As gastric atrophy worsened, H. pylori dominance remained stable while overall microbial diversity declined.