- Patients with ulcerative colitis and three or more allergic diseases were over eight times more likely to achieve mucosal healing.
- Pollen allergy and food allergy were independently associated with higher odds of mucosal healing.
- The study suggests potential shared pathophysiological mechanisms between ulcerative colitis and allergic diseases, particularly Th2-mediated immune responses involving cytokine IL-4.
- Further research is needed to explore these immunological links and their clinical implications.
- Data from 289 Japanese patients with ulcerative colitis was analyzed to assess the association between allergic diseases and mucosal healing (MH).
- Multivariate logistic regression analyses adjusted for various confounders, such as age, sex, body mass index, smoking, alcohol use, and medication exposure.
- MH was achieved in 24.6% of the cohort overall.
- No significant association was observed between allergic diseases and clinical remission.
Allergic Multimorbidity Linked to Mucosal Healing in UC
Conexiant
January 14, 2025
