- Patients with achalasia and prior esophageal Candida infection have an over eightfold increased risk of developing esophageal cancer.
- Esophageal Candida infection is a significant risk factor for esophageal cancer, particularly in patients with squamous cell carcinoma.
- Regular endoscopic monitoring is recommended for early detection of esophageal cancer in patients with achalasia.
- Male sex and older age at diagnosis were also independently associated with increased esophageal cancer risk.
- Patients with esophageal squamous cell carcinoma had an even stronger association with Candida infection.
- Ongoing susceptibility associated with prolonged food retention and esophageal conditions was highlighted.
- The study recommends increased surveillance for esophageal Candida infection in patients with achalasia.
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