5 Key Takeaways

• 1

  A study found that participants with prediabetes and higher BT2160 gut microbiota abundance had greater fasting blood glucose reduction with broccoli sprout extract.

• 2

  The randomized trial included 74 drug-naive participants aged 35 to 75 with impaired fasting glucose and a BMI of 27 to 45 kg/m².

• 3

  Broccoli sprout extract treatment resulted in a mean fasting glucose reduction of 0.2 mmol/L, which did not meet the primary outcome threshold of 0.3 mmol/L.

• 4

  Adverse effects, mainly gastrointestinal symptoms, were reported more frequently in the broccoli sprout extract group compared to the placebo group.

• 5

  Exploratory analyses indicated that a subgroup with MARD-like characteristics showed a 0.4 mmol/L reduction in fasting glucose, linked to gut microbiota composition.