Clinical Report: Broccoli Sprout Extract in Prediabetes: Microbiota and Glycemic Variability

Overview

A randomized trial evaluated the effects of broccoli sprout extract (BSE) on fasting blood glucose in prediabetic participants. BSE treatment resulted in a mean fasting glucose reduction of 0.2 mmol/L, which did not meet the primary outcome threshold of 0.3 mmol/L.

Background

Prediabetes is a significant public health concern, as it increases the risk of developing type 2 diabetes (T2D). Effective prevention strategies are crucial to mitigate the morbidity and mortality associated with T2D. The role of dietary interventions in managing glycemic levels in prediabetes warrants investigation.

Data Highlights

The study included 74 participants aged 35 to 75 years with impaired fasting glucose. Participants received either BSE or placebo for 12 weeks, with primary and secondary outcomes measured.

Key Findings

• BSE treatment resulted in a mean fasting glucose reduction of 0.2 mmol/L compared to placebo (P = .04).
• The primary outcome of a 0.3 mmol/L reduction was not achieved.
• Exploratory analyses identified a subgroup with MARD-like characteristics that exhibited a 0.4 mmol/L reduction in fasting glucose (P = .008).
• Participants with higher baseline BT2160 abundance showed greater sulforaphane serum concentrations (P = .046).
• Adverse effects, primarily gastrointestinal symptoms, were reported more frequently in the BSE group.
• No significant differences were observed in secondary outcomes, including BMI and insulin resistance.

Clinical Implications

Further research is needed to explore the role of gut microbiota in metabolic responses to BSE.

Conclusion

Further validation in larger cohorts is necessary.

Related Resources & Content

1. Dwibedi C., et al., Nature Microbiology, 2023 -- Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial
2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Emerging Strategies for Preventing Type 2 Diabetes
3. Frontiers in Endocrinology, 2023 -- Effect of probiotics derivatives (postbiotics and metabiotics) on glycemic control in individuals with type 2 diabetes: a randomized clinical trial (DELI_Diab study)
4. American Diabetes Association, 2026 -- Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes
5. NIDDK -- Diabetes Prevention Program (DPP)
6. conexiant — Medical Oddities: Spud Alert, Method Matters Most
7. conexiant — Early Gut Microbiota Predicts GDM
8. 3. Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes—2026 | Diabetes Care | American Diabetes Association
9. Diabetes Prevention Program (DPP) - NIDDK
10. Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial | Nature Microbiology