- Serum type I interferon scores predict disease progression in limited cutaneous systemic sclerosis.
- High IFN scores are associated with shorter time to clinical worsening.
- Combining IFN scores with clinical features improves risk stratification.
- Factors associated with clinical worsening include pulmonary arterial hypertension, interstitial lung disease, digital ulcers, and modified Rodnan Skin Scores.
- Integration of IFN scores into clinical practice could aid in patient management and stratification in clinical trials.
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