- Opposing effects on mortality: Higher oxidative balance was linked to lower mortality, while higher systemic inflammation was linked to increased mortality in RA.
- Magnitude of risk: Each 1-point increase in OBS reduced mortality risk by 4%, while each 1-unit increase in SIRI increased risk by 14%; high SIRI was associated with more than double the mortality risk.
- Combined risk matters most: The worst survival was observed in patients with both high inflammation and low oxidative balance, highlighting a joint effect.
- Effect may depend on inflammation level: The apparent benefit of higher oxidative balance was observed mainly in patients with elevated inflammation and was not significant in those with lower inflammation.
- Inflammation may mediate risk: Antioxidant status appeared to reduce mortality risk partly by lowering systemic inflammation, accounting for about 15% of the association.
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