5 Key Takeaways

• 1

  Patients with lupus nephritis who stopped immunosuppressive therapy after 48 months of complete renal response had a lower relapse risk.

• 2

  Younger patients, aged 34 years or younger, faced over a threefold increased risk of renal relapse after therapy withdrawal.

• 3

  The study analyzed 76 patients with biopsy-confirmed proliferative lupus nephritis who had maintained complete renal response.

• 4

  Factors associated with reduced relapse risk included longer IST duration, maintaining CRR for 48 months, and gradual IST tapering.

• 5

  Following IST reintroduction, 68.9% of relapsed patients achieved complete renal response, while some progressed to end-stage renal disease.