- Abnormal sugar attachments on IgG antibodies in pediatric lupus nephritis may disrupt kidney cell metabolism.
- IgG glycosylation differed in patients with active renal involvement compared to those without renal disease.
- Podocytes treated with lupus nephritis IgG showed lower glycolytic activity and reduced energy production, reversible upon removal of abnormal sugars.
- Metabolomics analysis identified altered glycolytic intermediates in podocytes exposed to lupus nephritis IgG.
- IgG glycosylation may differentiate patients with SLE and kidney disease, and serve as a tool to monitor treatment response or identify at-risk patients.
- The study tracked the effects of IgG glycosylation on podocyte function using digital polymerase chain reaction, Seahorse metabolic analysis, and cell imaging.
Source: Arthritis & Rheumatology
