Research has established HLA-B*52 as the most significant genetic risk factor for Takayasu arteritis (TAK), a rare inflammatory condition affecting large arteries, particularly in women under 50. The study analyzed data from five genome-wide association studies, identifying various loci linked to the disease. The findings indicate significant genetic risk variability across populations. While genetic factors contribute to TAK, the disease's multifactorial nature emphasizes the need for clinical context when interpreting genetic risk and underscores the potential for future therapeutic pathways.

Source: ACR open rheumatology