1. HLA-B*52 is the strongest genetic risk for Takayasu arteritis (TAK).
2. TAK commonly affects women under 50.
3. Confirmed variability in genetic risk across populations.
4. Included data from 5 GWAS involving diverse populations.
5. Key genes like IL6 and ETS2 are involved in immune response.
6. 99.99% of HLA-B*52 carriers do not develop TAK.
7. Findings guide future functional studies and therapies.

Source: ACR open rheumatology