- Mendelian randomization study links copper and iron levels to fibromyalgia risk. Elevated copper associated with increased risk, higher iron showed a protective effect.
- Mechanistically, excessive copper can cause cellular damage through oxidative stress.
- Abnormalities in iron metabolism may be related to neurotransmitter dysregulation and impaired immune cell functions.
- Fibromyalgia affects 2-8% of the global population, with higher prevalence in women.
- Patients with fibromyalgia exhibit a range of symptoms impacting daily lives and work capabilities.
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