- Patients with gout initiating urate-lowering therapy had a lower risk of cardiovascular events if prescribed colchicine for flare prophylaxis.
- Only 16.1% of patients received gout flare prophylaxis, despite international guidelines recommending colchicine during the first 3-6 months of ULT initiation.
- The study used robust statistical methods, including inverse probability of censoring weighting.
- Diarrhea was more common in the colchicine group.
- The study emphasized the need for randomized controlled trials to confirm a causal relationship.
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