- Circulating miR-126-3p identified as a biomarker for radiographic knee osteoarthritis.
- Elevated levels consistently found in affected individuals, showing diagnostic potential.
- Tissue analysis revealed highest expression in adipose tissue, synovium, and subchondral bone.
- miR-126-3p mimics in mice reduced cartilage degradation and synovitis.
- In vitro, it suppressed angiogenesis-related gene expression, suggesting a role in disease progression.
Source: Nature Communications
