5 Key Takeaways

• 1

  A systematic review of 44 trials evaluated cognitive behavioral therapy, interpersonal therapy, behavioral activation, and nondirective counseling for perinatal depression.

• 2

  Cognitive behavioral therapy and interpersonal therapy probably reduce depressive symptoms compared to usual care, with moderate strength of evidence.

• 3

  Behavioral activation may also reduce depressive symptoms, but the strength of evidence is low due to the limited number of studies.

• 4

  Nondirective counseling may show no difference compared to usual care, with low strength of evidence for its effectiveness.

• 5

  Most trials had moderate risk of bias, and findings may not generalize to low-resource or underrepresented populations.