- Core signature: Psychedelics consistently increase connectivity between transmodal (default, frontoparietal) and unimodal (sensory/motor) networks.
- Subcortical involvement: Strong, reproducible changes occur in striatal regions (caudate, putamen), linking them more tightly with cortical networks.
- Within-network effects are limited: Reductions in within-network connectivity are modest, selective, and less consistent than previously reported.
- Shared mechanism across drugs: Despite pharmacologic differences, multiple psychedelics show a common large-scale brain network “reconfiguration” pattern.
- Improved methodological clarity: Using a Bayesian mega-analysis helps resolve inconsistencies in prior studies and highlights the most reliable, cross-dataset effects.
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