5 Key Takeaways

• 1

  Over one-third of patients with major depressive disorder underwent four or more antidepressant trials during a single episode.

• 2

  The study identified 2,461 patients with treatment-resistant depression, representing 47.9% of those meeting eligibility criteria.

• 3

  Patients with treatment-resistant depression had higher rates of recurrent depression, anxiety disorders, and personality disorders compared to nonresistant MDD.

• 4

  Cardiovascular comorbidities, smoking-related diagnoses, and type 2 diabetes were more prevalent in the treatment-resistant depression group.

• 5

  Qualitative interviews revealed barriers to effective care, including inconsistent terminology and limited access to psychological services.