- Higher MDASI-HN-NERVE scores were associated with increased hypoglossal nerve neuropathy risk, with each 1-point increase linked to a 1.35-fold higher hazard.
- A composite symptom score threshold of 3.4 at baseline and 3.5 at 3 to 6 months posttreatment differentiated patients with higher vs lower neuropathy-free survival over 5 years.
- Patients with speech or voice scores of at least 2 at 3 to 6 months had substantially higher neuropathy risk during follow-up.
- Symptom trajectories differed by neuropathy status, with persistent or worsening speech, swallowing, choking, and mucus symptoms observed among patients who later developed neuropathy.
- Researchers emphasized that the symptom measures are intended for risk stratification and surveillance rather than diagnostic confirmation, and that external validation is needed before clinical implementation.
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