- Early pain reduction: Prednisolone lowered resting pain at one and two weeks, but not pain during activity.
- Short-term functional signals: Improvements in sleep quality (2 weeks), knee function score (2 weeks), and range of motion (4 weeks) were observed before adjustment.
- Age adjustment matters: The celecoxib-alone group was older at baseline, and after adjustment, most early differences were no longer statistically significant.
- No durable benefit: By 24 weeks, outcomes were similar overall, with Knee Society Score favoring celecoxib alone.
- Clinical relevance limited: Improvements did not consistently reach minimal clinically important difference thresholds and should be interpreted cautiously.
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