A large UK study found no significant difference in treatment effectiveness between abatacept and adalimumab for rheumatoid arthritis, regardless of patients’ HLA-DRB1 genetic profiles.
In a phase 3 trial, a purified human fibrinogen concentrate reduced intraoperative blood loss and lowered thromboembolic risks compared with fresh frozen plasma or cryoprecipitate during major surgeries.
A new review comparing knee implant methods in obese patients finds cementless fixation may improve implant survival and reduce loosening compared with cemented approaches, especially in patients with BMI ≥35 kg/m².
A 52-week randomized clinical trial found no significant difference between methotrexate and placebo in reducing pain or effusion-synovitis in patients with inflammatory knee osteoarthritis.
The UK hospital study of over 80,000 patients found that certain opioids, including morphine and oxycodone, carried a higher risk of severe constipation compared with others.
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A sweeping 30-year review confirms the Mediterranean-style diet lowers risks of heart disease, diabetes, cancer, and cognitive decline—while supporting global sustainability.
EASO’s expanded obesity definition incorporating waist-to-height ratio and comorbidities reclassifies 18.8% of overweight adults, but mortality benefits remain uncertain.