Objective:

To evaluate the impact of universal aspirin dispensation on the rate of preeclampsia with severe features in high-risk pregnancies.

Key Findings:

• Preeclampsia with severe features (SPE) rate decreased from 7% to 5%.
• Time to SPE diagnosis was significantly longer in the aspirin group.
• Gestational hypertension rates declined from 21% to 19%.
• Preterm delivery before 37 weeks reduced from 10% to 9%.
• Postpartum hemorrhage rates decreased from 9.5% to 8.9%.

Interpretation:

Aspirin administration in high-risk pregnancies appears to delay or prevent the onset of preeclampsia with severe features without significant harm.

Limitations:

• Observational study design limits causation inference.
• Results may not generalize to other populations with different risk profiles.

Conclusion:

Directly-dispensed aspirin in high-risk pregnancies showed promising results in reducing severe preeclampsia rates without adverse effects.