5 Key Takeaways

• 1

  A 3-year trial found omega-3 treatment did not significantly reduce white matter lesion progression in older adults at risk for dementia.

• 2

  The study included 102 participants aged 75 and older, with 28% being APOE*E4 carriers.

• 3

  Among APOE*E4 carriers, omega-3 treatment resulted in significantly less neuronal integrity breakdown compared to placebo.

• 4

  Adverse events were similar between omega-3 and placebo groups, with serious events occurring in 31.4% of participants in both groups.

• 5

  The study authors noted limitations including a homogeneous population and potential underpowering for detecting WML accumulation.