- Uric acid stone dissolution increased sharply as urine pH rose above 6.5.
- Peak dissolution occurred at urine pH 7.2 in the in vitro model.
- Ground stone fragments dissolved approximately 10-fold faster than intact stones.
- Lowering urinary uric acid concentrations had limited effect without adequate alkalinization.
- Findings supported European Association of Urology recommendations targeting urine pH 7.0 to 7.2 for oral chemolysis.
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