1. Sinonasal squamous cell carcinoma (SNSCC) arises in the nasal cavity and paranasal sinuses.
2. HPV-associated and HPV-independent SNSCC tumors exhibited distinct genetic alterations and mutational signatures.
3. Genetic analysis revealed distinct tumorigenic pathways for the two groups.
4. Certain mutations, such as TP53 mutations in HPV-independent SNSCC, were linked to decreased survival.
5. HPV-associated tumors showed frequent mutations in KMT2D, FGFR3, and KMT2C, while HPV-independent tumors exhibited high frequencies of TP53 mutations.
6. HPV-associated tumors demonstrated strong APOBEC signature mutational pattern, common in HPV-driven cancers.
7. The study highlighted a need for precision treatments based on HPV status and specific genetic alterations.

Source: Nature Communications