• Frequent migraine requires combined acute and preventive management strategies.
• Triptans and calcitonin gene-related peptide-targeting agents are central to modern therapy.
• Preventive therapy selection should be individualized based on comorbidities.
• Accurate diagnosis and assessment of attack frequency guide treatment decisions.
• Migraine remains a leading cause of disability, highlighting need for optimized care.

Source: Annals of Internal Medicine