Objective:

To investigate the association between dietary niacin intake and kidney stone prevalence among U.S. adults.

Approach:

• Study Design: Cross-sectional analysis using data from the National Health and Nutrition Examination Survey (2007-2018) involving 28,508 participants.
• Data Collection: Dietary niacin intake assessed through 24-hour dietary recall interviews, excluding supplements.
• Analysis Methods: Weighted logistic regression models, restricted cubic spline analysis, and stratified analyses were employed.

Key Findings:

• Participants with the highest dietary niacin intake had a 22% lower risk of developing kidney stones compared to those with the lowest intake.
• In fully adjusted models, the odds ratio for kidney stones in the highest niacin quartile was 0.78 (95% CI = 0.63–0.97; P = .027).
• Higher niacin intake as a continuous variable was associated with reduced kidney stone risk (OR = 0.83; 95% CI = 0.71–0.96; P = .013).
• The inverse association was more pronounced in participants younger than 60 years.

Interpretation:

Limitations:

• The cross-sectional nature of the study limits causal interpretation.
• Further prospective studies are needed to validate these results and investigate underlying mechanisms.

Conclusion:

Sources:

• Scientific Reports