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Conexiant chevron_right Internal Medicine chevron_right Early Research Finds Aspirin May Block Cancer Spread by Boosting Immune Response
From the Journals

Early Research Finds Aspirin May Block Cancer Spread by Boosting Immune Response

Preclinical study demonstrates that aspirin may prevent cancer metastasis by inhibiting platelet-produced TXA2, which normally suppresses T-cell immunity against spreading cancer cells.

Conexiant
article Full Article subject Summary summarize Notecard
  1. Aspirin's effects on cancer metastasis involve a molecular pathway via platelet-derived thromboxane A2 (TXA2).
  2. TXA2 signaling suppresses T cell immunity to cancer metastasis through an ARHGEF1-dependent pathway, inhibiting immune surveillance against cancer metastasis.
  3. Aspirin's anti-metastatic effects primarily target COX-1, supporting more selective therapeutic strategies.
  4. Aspirin and selective COX-1 inhibitors may reduce metastasis frequency.

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