Colorectal cancer is the leading cause of cancer death in men under 50 in the US, indicating a need for a shift in cancer risk assessment.
Seventy-five percent of 42 countries reported rising early-onset cancer incidences, with Generation X and Millennials facing higher risks.
Current epidemiologic tools are inadequate for understanding early-onset cancers, as most major cohorts begin in midlife.
Only 30% to 45% of cancers are linked to established modifiable causes, highlighting the need for better measurement of exposures.
The authors propose frameworks for advancing cancer research, emphasizing the importance of treating early-onset cancer as a life-course issue.
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
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