1. Combination of known and unknown life-course factors contribute to chronic diseases.
2. Midlife clinical indicators, lifestyle habits, and socioeconomic status are strong predictors.
3. Many chronic conditions share common risk factors.
4. Further research is needed to identify additional contributors, including genetic predispositions and environmental exposures.
5. Study covered 2,003 participants born in Helsinki between 1934 and 1944, with medical records analyzed over 30 years.
6. Lifestyle habits, such as smoking, diet, alcohol use, and physical activity, significantly affected disease accumulation.
7. The upper limit of explainability was 75%, indicating that familiar risk factors explained only part of the variance.

Source: The Lancet