- Substantial increase in appendiceal adenocarcinoma (AA) incidence among younger U.S. birth cohorts, particularly after 1980.
- Mucinous, nonmucinous, goblet cell, and signet ring cell adenocarcinomas all showed increased incidence across recent generations.
- Detection bias was unlikely to explain these trends.
- Limited case counts did not allow for stratification of incidence by sex or race.
- Increasing AA incidence mirrors trends in other gastrointestinal cancers, suggesting shared risk factors.
- Authors emphasize the need for further etiologic research and improved awareness and early detection strategies for this rare malignancy.
Source: Annals of Internal Medicine
