Circulating Insulin-like peptide 5 concentrations may reflect colonic exposure to bile acids and help stratify treatment response in patients with chronic diarrhoea, including those with irritable bowel syndrome with diarrhoea and bile acid diarrhoea.
A 3-year analysis of a phase IIIb trial found that bimekizumab, a dual interleukin-17A and interleukin-17F inhibitor, maintained high rates of skin clearance and demonstrated a consistent safety profile in patients with moderate-to-severe plaque psoriasis, including those who switched from secukinumab, an interleukin-17A inhibitor.
An international cohort study found that patients with sludge- or microlithiasis-induced acute pancreatitis had significantly fewer long-term complications than those with gallstone-related pancreatitis.
Home use of ondansetron following emergency care for pediatric gastroenteritis lowers the risk of moderate-to-severe illness within 7 days, without increasing serious adverse events.
In a 48-week analysis of 1021 adults with moderate-to-severe Crohn’s disease, guselkumab outperformed placebo and ustekinumab in endoscopic and composite clinical endpoints.
New clinical recommendations detail updated vaccination and screening protocols to reduce infection and cancer risks in adults with inflammatory bowel disease, particularly those on immune-modifying therapies.
The UK hospital study of over 80,000 patients found that certain opioids, including morphine and oxycodone, carried a higher risk of severe constipation compared with others.