1. Weight regain after substantial weight loss following bariatric surgery was found to be associated with less favorable cardiovascular risk profile and increased incidence of microvascular and macrovascular diseases. 
2. Overall mortality rates remained nearly identical despite weight regain. 
3. Study included 1,346 participants who underwent bariatric surgery between 1987 and 2001 with a median follow-up of 27 years. 
4. Future research is needed to explore additional long-term consequences of weight regain and strategies for maintaining weight loss. 
5.  Long-term monitoring and interventions are important to reduce cardiovascular risk in patients who regain weight post-surgery.

Source:  The Lancet Regional Health - Europe